Tumor Microenvironmental Conversion of Natural Killer Cells into Myeloid-Derived Suppressor Cells
نویسندگان
چکیده
منابع مشابه
Tumor microenvironmental conversion of natural killer cells into myeloid-derived suppressor cells.
How myeloid-derived suppressor cells (MDSC) emerge in the tumor environment remains unclear. Here, we report that GM-CSF can convert natural killer (NK) cells into MDSCs. When transferred into tumor-bearing mice, adoptively transferred NK cells lost their NK phenotype and were converted into Ly6C(high)Ly6G(high) MDSC. This conversion was abolished by exposure to IL-2 either in vitro or in vivo....
متن کاملMicroenvironment and Immunology TumorMicroenvironmental Conversion of Natural Killer Cells into Myeloid-Derived Suppressor Cells
How myeloid-derived suppressor cells (MDSC) emerge in the tumor environment remains unclear. Here, we report that GM-CSF can convert natural killer (NK) cells intoMDSCs.When transferred into tumor-bearingmice, adoptively transferred NK cells lost their NK phenotype and were converted into Ly6CLy6G MDSC. This conversion was abolished by exposure to IL-2 either in vitro or in vivo. Notably, we fo...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2013
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-13-0545